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Generic venlafaxine cost -effectiveness, the use of venlafaxine appears to be cost-reducing in comparison with its other SSRI siblings, an estimated marginal benefits of $2300 vs $6100 per person over a follow-up of up to 5 years. A number of reasons account for this finding: (1) the initial costs of venlafaxine compared with other SSRI's are considerably less; (2) unlike some other SSRIs, venlafaxine does not have a substantial propensity to cause weight gain in patients with depression; (3) venlafaxine is considerably less likely than other SSRI antidepressants to induce somatic and cognitive symptoms; (4) due to its potential for rapid dissolution of monoamines, venlafaxine has the lowest cardiovascular Generic tobradex ophthalmic ointment risk of all SSRIs. A number of studies have explored the combination of venlafaxine and tricyclic antidepressants, but results are inconclusive.[29,31,32] Venlafaxine generally appears to produce fewer effects on fatigue, irritability, and anxiety when added to an SSRI, but this difference is minimal, and results are equivocal on any other symptom. Moreover, these studies are confounded by a small baseline difference between venlafaxine and tricyclic antidepressants, while other studies found no interaction between the two classes of medications.[32] Despite these uncertainties, one large meta-analysis concluded that adding venlafaxine to a SSRI generally had no Flector patch in uk overall effect on treatment outcome,[33] and the use of more than one SSRI does not generally enhance the therapeutic efficacy of either antidepressant.[34] Venlafaxine appears superior to antidepressants in the treatment of major depressive disorder due to its better tolerability, lower risk of Sildenafil generico mexico side effects, and lower cost. Antidepressants, but not placebo, significantly improve fatigue, depression, and anxiety in patients with major depression over a six-week treatment period.[35] These benefits include less fatigue with venlafaxine and fewer side effects with venlafaxine for women.[36] However, these benefits are limited to major depressive disorder, and do not extend to other medical conditions, such as obsessive-compulsive disorder, or chronic pain. A meta-analysis of 12 studies venlafaxine vs antidepressants examined the effects of venlafaxine versus placebo in the treatment of depression.[37] No significant difference was found for treatment outcome or any of the primary quality variables in comparison between venlafaxine and antidepressants on an aggregate or per treatment effectiveness measure. Moreover, the pooled effect sizes for efficacy of venlafaxine were significantly less in magnitude than those of antidepressants. Further, the study Venkataraman et al.[38] concluded that venlafaxine vs antidepressants was not superior to placebo. Many of the randomized clinical trials venlafaxine were performed before its selective serotonin reuptake inhibition (SSRI) mechanism of action was fully elucidated.[39] This lack of information may lead to bias, and results from randomization studies are generally susceptible to the occurrence of confounding variables such as prior treatment history or patient characteristics. These weaknesses have probably contributed to the widely reported relative lack of benefit venlafaxine to its competitors on major depressive disorder.[3] Despite the lack of benefit observed in randomized controlled trials, venlafaxine appears to be more highly effective for severe depression, with an estimated marginal benefit and cost/benefit ratio an estimated cost-effectiveness of $1670 vs $1400 per person over a 50-day trial period[8] generic venlafaxine cost (see Figure 1) which suggests a better value than fluoxetine. Venlafaxine has no effect venlafaxine er generic price on the severity of irritability or anxiety.[9] These advantages are consistent with those observed by Shulmans[40] in their review of SSRIs. Figure 1. Venlafaxine cost-effectiveness versus fluoxetine Source: "Cost-effectiveness of SSRIs: Meta-analysis selected randomized controlled trials, 2003-2008" published in 2010 the Clinical Pharmacology & Therapeutics journal. Volume 56, Issue 4, pages 653-661. In addition to its cost-effectiveness ratio, there is little evidence that fluoxetine (SNRI) is effective in more than a narrow subgroup of patients with major depressive disorder. For example, many patients receiving fluoxetine (SNRI) appear to have comorbidity with bipolar disorder, anxiety disorders, or substance use which complicates their ability to adjust other treatments.[41] For women patients with major depressive disorder, venl.

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